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August 15, 2025OncoImmunologyOpen Access

A phase 2 trial of CXCR4 antagonism and PD1 inhibition in metastatic pancreatic adenocarcinoma reveals recruitment of T cells but also immunosuppressive macrophages

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Authors

KBKatherine M. BeverSSSarah M. ShinJDJennifer N. Durham

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Overview

Phase 2 trial finds T cell recruitment but increased immunosuppressive macrophages in patients with PDAC.

Key Points

  • Immune cell mobilization was confirmed after treatment, highlighting fluid dynamics within the tumor environment.
  • The objective response rate to the combination therapy was limited, with only two out of twenty-one patients achieving stable disease.
  • Observational analysis revealed an increase in macrophages alongside T cells post-treatment, impacting immune interactions.
  • Macrophage-targeting strategies showed promise but indicated the complexity of the immune response in pancreatic cancer.

Cite This Study

Bever et al. (2025) studied this question.

synapsesocial.com/papers/68af2b68cf1dd9ea359e4df1https://doi.org/10.1080/2162402x.2025.2543614
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multi-omics analyses inform mechanisms of immunotherapy response in pancreatic cancer2025
  2. 2Neutrophil Extracellular Traps Modulate Recruitment and Immunosuppression of Macrophages in Pancreatic Adenocarcinoma 2025
  3. 3Strategies to Target the Tumor-Associated Macrophages in the Immunosuppressive Microenvironment of Pancreatic Ductal Adenocarcinoma2025
  4. 4Non-redundant immune checkpoints direct therapeutic resistance to chemoimmunotherapy in pancreatic ductal adenocarcinoma2025
  5. 5Data from Neutrophil Extracellular Traps Modulate Recruitment and Immunosuppression of Macrophages in Pancreatic Adenocarcinoma2025 · 1 citations