Biomimetic Hematoma Enables Healing in a Recalcitrant Nonunion With Chronic Osteomyelitis and 20 Prior Surgeries

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Complete bony union achieved at 6 months without infection recurrence, marking a significant recovery milestone.
Patient underwent 20 prior surgeries due to complications from a nonunion and infection before this intervention.
Biomimetic hematoma scaffold utilized along with low-dose rhBMP-2 for regeneration, providing innovative treatment for recalcitrant cases.
Procedure involved correcting deformity with a Taylor Spatial Frame and using Cerement G to manage infection.

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Case report demonstrates successful healing of a nonunion in a patient with osteomyelitis, suggesting the effectiveness of a biomimetic hematoma.

Maestas et al. (2025) studied this question.

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Case report demonstrates successful healing of a nonunion in a patient with osteomyelitis, suggesting the effectiveness of a biomimetic hematoma.