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August 8, 2025Frontiers in ImmunologyOpen Access

Immunotherapy in biliary tract cancer: reshaping the tumour microenvironment and advancing precision combination strategies

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Authors

JXJingnan XueLZLonghao ZhangKZKai Zhang

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Overview

Review highlights immunotherapy and combination strategies, emphasizing the complex tumour microenvironment in biliary tract cancer.

Key Points

  • Immunotherapy has shown promise in treating biliary tract cancer but faces challenges from the tumour microenvironment.
  • Research suggests that combining immune checkpoint inhibitors with chemotherapy can improve clinical outcomes.
  • This review analyzes the genetic factors contributing to biliary tract cancer and the role of immune cells in resistance.
  • Emerging treatments like CAR-T-cell therapy and mRNA vaccines indicate new pathways for personalized care in patients.

Cite This Study

Xue et al. (2025) studied this question.

synapsesocial.com/papers/68af2b63cf1dd9ea359e4b64https://doi.org/10.3389/fimmu.2025.1651769
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