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August 8, 2025Frontiers in Molecular NeuroscienceOpen Access

S-9-PAHSA ameliorates cognitive decline in a type 2 diabetes mouse model by inhibiting oxidative stress and apoptosis via CAIII modulation

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Authors

XWXinru WangSHShan-Shan HuangMWMeng Wang

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Overview

Observational analysis demonstrates improved cognitive function in T2DM mice, highlighting CAIII's role in oxidative stress and apoptosis.

Key Points

  • S-palmitic acid-9-hydroxy stearic acid significantly improves cognitive function in T2DM mice, enhancing spatial memory.
  • CAIII was identified as a crucial player in SP's effects, with improvements in oxidative stress and apoptosis noted.
  • Analysis employed Morris water maze tests alongside various cellular assays to assess cognitive and cellular impacts.
  • This research suggests CAIII as a potential therapeutic target for cognitive disorders related to diabetes.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68af2b63cf1dd9ea359e4a08https://doi.org/10.3389/fnmol.2025.1617543
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