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June 16, 2025Advances in Laboratory Medicine / Avances en Medicina de LaboratorioOpen Access

Circulating tumor DNA in patients with cancer: insights from clinical laboratory

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Authors

FIFrancisco J. IllanaEFEsther Fernández‐GalánJMJosé Luis Muñoz‐Bravo

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Overview

Review highlights clinical applications of circulating tumor DNA, somatic mutations, and biomarkers in cancer treatment.

Key Points

  • Blood-based circulating tumor DNA analysis provides insights into the genetic landscape of cancers, enhancing personalized treatment.
  • Somatic mutation analysis is being increasingly used to guide targeted therapies for patients with advanced cancers, improving outcomes.
  • Recent advancements in PCR and NGS-based methods are enabling more accurate assessments of gene variants in circulating tumor DNA.
  • Despite significant progress, challenges like standardization and assay sensitivity must be addressed for effective clinical implementation.

Cite This Study

Illana et al. (2025) studied this question.

synapsesocial.com/papers/68af2b5ccf1dd9ea359e4815https://doi.org/10.1515/almed-2025-0010
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