Molecular analysis reveals complete genotype turnover of DENV-1 in southeastern China, highlighting the need for continued genomic monitoring.
Key Points
Complete genotype turnover of DENV-1 occurred between 2019 and 2024, indicating significant strain replacement and pressure on local transmission patterns.
Phylogenetic analysis identified distinct clades for 2019 and 2024 DENV-1 isolates, demonstrating clear lineage displacement dynamics.
Whole-genome sequencing and selection pressure analysis revealed conserved substitutions and antigenic variants, essential for vaccine development.
Eighteen recombination events were found, primarily involving strains from neighboring regions, emphasizing the importance of regional genetic connections.