August 8, 2025MicroorganismsOpen Access

Cervical Actinomycosis Diagnosed via Metagenomic Next-Generation Sequencing of Formalin-Fixed Paraffin-Embedded Tissue: A Case Report and Literature Review

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Case report reveals actinomycosis diagnosis through metagenomic sequencing in cervical tissue, highlighting diagnostic challenges.

Cervical actinomycosis was diagnosed using metagenomic next-generation sequencing of formalin-fixed paraffin-embedded tissue.
The detection of Actinomyces israelii accompanied by Methylobacterium supported the diagnosis, showing treatment success after oral amoxicillin.
This case demonstrates the potential of metagenomic sequencing as a reliable diagnostic tool for challenging infections.
Challenges persist in diagnosing cervical actinomycosis due to nonspecific symptoms, calling for enhanced awareness in clinical settings.

Wang et al. (2025) studied this question.

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