Development of a Vitamin C Derivative Serum for Pre-Aging Skin: Raw Material Screening, Stability and Clinical Evaluation

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The serum containing 10% 3-O-ethyl ascorbic acid significantly reduced dark spots by 4.25% and improved skin firmness by 20.35%.
Efficacy was evaluated on 39 women after 28 days using advanced dermatological tools, confirming significant results.
Stability was assessed under various conditions, with the 3-O-ethyl ascorbic acid proving to be the most stable vitamin C derivative.
This formulation offers a promising solution for combating signs of pre-aging, such as wrinkles and dull skin.

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Clinical evaluation of a serum with 10% 3-O-ethyl ascorbic acid shows improved skin elasticity and reduced dark spots.

Istiqomah et al. (2025) studied this question.

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