Observational analysis reveals spontaneous control of HIV-1 in women with high peak viraemia, indicating potential for treatment strategies.
Key Points
Spontaneous control of HIV-1 was observed in eleven women living in East Africa, lasting for an average of 891 days after diagnosis.
Viraemic controllers presented lower viral loads (1069 copies/ml) compared to non-controllers (24,084 copies/ml) at set point, highlighting significant differences.
The cohort analysis included participants from East Africa, focusing on the interplay between viral characteristics and host immune response.
Findings emphasize the potential of studying HIV-1 subtype A1 in East Africa to unlock new treatment avenues for durable HIV-1 remission.