August 11, 2025Frontiers in OncologyOpen Access

Synchronous papillary renal neoplasm with reverse polarity and multilocular cystic renal neoplasm of low malignant potential in unilateral kidney: case report with molecular analysis and literature review

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Both tumors were identified within the same kidney, highlighting a rare occurrence in renal pathology.
Histological analysis confirmed PRNRP and MC-LMP in a 70-year-old male, with genetic profiling revealing KRAS mutations and VHL alterations.
The assessment focused on differential diagnosis, crucial for distinguishing these tumors from more aggressive renal cell carcinoma types.
This case emphasizes the importance of determining genomic profiles in synchronous tumors to guide treatment strategies.

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Implication

Case report reveals synchronous papillary renal neoplasm with reverse polarity and multilocular cystic renal neoplasm, indicating the need for accurate identification in diagnosis.

Cite This Study

Nithagon et al. (2025) studied this question.

synapsesocial.com/papers/68af296ecf1dd9ea359e2c88 https://doi.org/10.3389/fonc.2025.1605192

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Implication

Case report reveals synchronous papillary renal neoplasm with reverse polarity and multilocular cystic renal neoplasm, indicating the need for accurate identification in diagnosis.

Synchronous papillary renal neoplasm with reverse polarity and multilocular cystic renal neoplasm of low malignant potential in unilateral kidney: case report with molecular analysis and literature review

Key Points

Discussion

Implication

Cite This Study

Synchronous papillary renal neoplasm with reverse polarity and multilocular cystic renal neoplasm of low malignant potential in unilateral kidney: case report with molecular analysis and literature review

Key Points

Discussion

Implication

Cite This Study