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August 11, 2025Frontiers in EndocrinologyOpen Access

Effect of high intakes of protein-only and carbohydrate-only on plasma metabolites and hormones, in addition to nitrogen excretion

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Authors

MCMatthieu ClaussCPC. PuissantNBNasser E. Bastani

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Overview

Randomized crossover trial assessed plasma metabolites and hormones after high protein and carbohydrate intake, suggesting distinct metabolic effects.

Key Points

  • CHO intake increases plasma insulin and glucose, while PRO intake elevates plasma amino acids and GLP-1.
  • Insulin concentrations rise post-ingestion of both types, with more significant increases following carbohydrate intake.
  • In a randomized crossover design, fourteen trained participants consumed whey protein or carbohydrate drinks under controlled conditions.
  • Higher urinary nitrogen excretion observed after protein intake, indicating increased protein degradation within 24 hours.

Cite This Study

Clauss et al. (2025) studied this question.

synapsesocial.com/papers/68af296ecf1dd9ea359e2c5bhttps://doi.org/10.3389/fendo.2025.1618142
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