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August 11, 2025Frontiers in Public HealthOpen Access

Down syndrome burden in China and globally: a comparative analysis of 1990–2021 trends and future projections based on GBD 2021 database

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Authors

XTXin TuFZFeng ZhangJCJunkun Chen

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Overview

Comparative analysis reveals declines in down syndrome burden in China and globally, highlighting future trends.

Key Points

  • From 1990 to 2021, down syndrome incidence decreased in both China and worldwide, indicating effective public health strategies.
  • China's age-standardized mortality rate for down syndrome fell by 4.18% annually, surpassing the global rate reduction of 0.44%.
  • Joinpoint regression identified significant declines across key metrics in China, with projected continuous reduction in prevalence through 2036.
  • These findings emphasize the importance of proactive measures for early detection and improved support for individuals with down syndrome.

Cite This Study

Tu et al. (2025) studied this question.

synapsesocial.com/papers/68af296ecf1dd9ea359e2b4ehttps://doi.org/10.3389/fpubh.2025.1632250
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