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August 11, 2025Frontiers in Cellular and Infection MicrobiologyOpen Access

Diagnostic performance and clinical utility of metagenomic next-generation sequencing in suspected central nervous system infections: a prospective comparative study

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Authors

XCXiao-guang CaoXZXiao ZhuYZYu Zha

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Implication

Prospective study assesses diagnostic performance of mNGS in confirming pathogens in suspected CNS infections, suggesting enhanced clinical utility.

Key Points

  • mNGS identified pathogens in 62 out of 69 diagnosed CNS infections, demonstrating a high detection rate.
  • Compared to traditional CSF culture, mNGS has a faster turnaround time of under 24 hours versus up to 120 hours.
  • Logistic regression shows mNGS predicts CNS infection, along with CSF protein and glucose levels having diagnostic value.
  • This study indicates mNGS may significantly improve individualized treatment strategies for patients with CNS infections.

Cite This Study

Cao et al. (2025) studied this question.

synapsesocial.com/papers/68af296ecf1dd9ea359e2952https://doi.org/10.3389/fcimb.2025.1612628
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