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August 11, 2025Frontiers in MicrobiologyOpen Access

Epidemiological and clinical impact of hepatitis E virus coinfection in chronic hepatitis B infected patients in Hebei, China

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Authors

YSYuzhu ShiYXYuchen XieYCYing Chen

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Implication

Cross-sectional study reveals 18.70% seroprevalence of hepatitis E in chronic hepatitis B patients, suggesting higher risk in older individuals.

Key Points

  • The seroprevalence of anti-HEV antibodies among chronic hepatitis B patients is 18.70%, highlighting significant coinfection risks.
  • Older age is a confirmed independent risk factor for increasing anti-HEV seropositivity (OR = 1.03, P < 0.001).
  • Patients with hepatitis B and previous hepatitis E infections show higher rates of liver cirrhosis and hepatocellular carcinoma.
  • Coinfection with hepatitis E may exacerbate liver injury and prolong coagulation times in hepatitis B patients.

Cite This Study

Shi et al. (2025) studied this question.

synapsesocial.com/papers/68af269bcf1dd9ea359e291bhttps://doi.org/10.3389/fmicb.2025.1638614
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