August 11, 2025Frontiers in PharmacologyOpen Access

Safety of oral JAK inhibitors in treating alopecia areata: a systematic review and network meta-analysis

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Discussion

Systematic review analyzes safety of JAK inhibitors in adults with alopecia areata, suggesting favorable profiles despite some risks.

Oral JAK inhibitors generally show a favorable safety profile for alopecia areata treatment, but specific risks exist.
The analysis reviewed 12 studies involving 3,840 participants, indicating possible side effects vary by drug.
Network meta-analysis was conducted using Bayesian methods for a comprehensive understanding of safety outcomes.
Baricitinib presents higher risks for acne and urinary infections compared to alternatives, highlighting safety concerns.

Qi et al. (2025) studied this question.

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