Exploration of bacteriophage therapy as a viable alternative to combat antibiotic-resistant bacterial infections: A comprehensive in vitro and in vivo evaluation

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In vitro and in vivo evaluations show bacteriophage therapy significantly reduces antibiotic-resistant bacteria, suggesting a new treatment approach.

Bacteriophage therapy reduced bacterial counts by up to 4.5 log₁₀ CFU/mL and improved survival in mice up to 85%.
The study found synergistic effects between phage therapy and antibiotics, which preserved gut microbiota without adverse effects.
This was a comprehensive evaluation performed both in vitro and in vivo on multidrug-resistant bacterial strains.
Bacteriophage therapy may enable new management strategies for antibiotic-resistant infections and raise treatment safety.

Mehta et al. (2025) studied this question.

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In vitro and in vivo evaluations show bacteriophage therapy significantly reduces antibiotic-resistant bacteria, suggesting a new treatment approach.