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August 17, 2025Clinical PhytoscienceOpen Access

Antidiabetic assessment of mango and soursop leaves bioactive phytochemical formulation on streptozotocin-induced rat model

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Authors

COChurchill Chisom OgbonnaSISamuel C. IwujiTATaofik Oladimeji Azeez

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Overview

This analysis demonstrates significant antidiabetic effects of mango and soursop leaf extracts on glucose levels in rats, suggesting potential therapeutic uses.

Key Points

  • The bioactive phytochemical formulation significantly reduced glucose levels in streptozotocin-induced rat models, showing promising antidiabetic properties.
  • Preliminary screening identified significant yields of saponins and flavonoids, with glucose reduction capacity indicating strong antidiabetic activity in the extracts.
  • Assessment involved cold maceration and GCMS analysis of phytochemicals, revealing high yields of active compounds like succinic acid and hexamethyl cyclotrisiloxane.
  • The research highlights the safe and effective use of plant-based extracts, suggesting further investigation into the clinical potential of mango and soursop formulations.

Cite This Study

Ogbonna et al. (2025) studied this question.

synapsesocial.com/papers/68a3531d234c60ad5c20dd91https://doi.org/10.1186/s40816-025-00395-0
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