Analysis demonstrates improved prediction of major adverse cardiovascular events in individuals using inflammation-related proteins, indicating better risk stratification.
Key Points
Incorporating inflammation-related proteins into the SCORE2 model significantly improves 10-year MACE risk prediction among individuals without prior CVD or diabetes.
The C-index improved from 0.716 to 0.750 in the UK Biobank, demonstrating stronger predictive capability with added biomarkers.
Analysis was based on data from over 51,000 participants across the UK Biobank and German ESTHER study, employing LASSO regression for biomarker selection.
These findings may help in better risk stratification in clinical practice, enhancing the prediction accuracy for cardiovascular events.