Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 15, 2025Fundamental and Clinical PharmacologyOpen Access

No Impact of Vancomycin MIC, AUC, or AUC/MIC in Enterococcus faecium Bacteremia

View Full Paper
Ask AI
Bookmark
Share

Authors

ALAnne LimeletteTTThibaut TromeurRRRami Rhaiem

Discussion

Loading...

Member takes

Overview

Observational study shows no association between vancomycin MIC, AUC, and in-hospital mortality in patients with E. faecium bacteremia, indicating limitations in PK/PD target determination.

Key Points

  • In-hospital mortality was not associated with vancomycin MIC or amoxicillin susceptibility in patients with E. faecium bacteremia.
  • The median vancomycin MIC observed was 0.5 mg/L, with 67 of 207 patients (32.3%) dying during hospitalization.
  • Retrospective analysis was used to assess clinicobiological data from patients with severe comorbidities.
  • Findings highlight the potential inadequacy of using retrospective studies to determine PK/PD targets for vancomycin.

Cite This Study

Limelette et al. (2025) studied this question.

synapsesocial.com/papers/689fc962e46e096235ce1d8fhttps://doi.org/10.1111/fcp.70039
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1<i>In vitro</i> and <i>in vivo</i> efficacy of vancomycin against <i>Elizabethkingia</i> species and the impact of increased vancomycin MICs2025
  2. 2Clinical Outcomes and Molecular Epidemiology of Vancomycin-Resistant Enterococcus faecium Bloodstream Infection: The Importance of Appropriate Therapy and ST17 Predominance2026
  3. 3Association between daptomycin dosing and in-hospital mortality in patients with vancomycin-resistant <i>Enterococcus faecium</i> bloodstream infection2025
  4. 4Vancomycin Exposure Dynamics and Clinical Outcomes in Critically Ill Patients: A Retrospective Cohort Study2026
  5. 5Paediatric Enterococcal Bacteremia: An Exploration of the Clinical Impact With Emphasis on Antibiotic Resistance2025