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August 14, 2025

Efficacy and Tolerability of Finerenone According to the Use and Dosage of Diuretics: A Prespecified Analysis of the FINEARTS-HF Randomized Clinical Trial.

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Authors

MCMisato ChimuraOsaka Gakuin UniversityPJPardeep S. JhundBrigham and Women's HospitalAHAlasdair D HendersonUniversity of London

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Implication

Randomized clinical trial assesses finerenone's effects on heart failure outcomes in patients on various diuretics, suggesting it may reduce diuretic use.

Key Points

  • Finerenone reduced the risk of heart failure events compared to placebo across all diuretic subgroups.
  • Primary outcome data indicated that 45.9% of participants were female, with an average age of 72.1 years.
  • Randomized clinical trial analysis revealed consistent efficacy and safety of finerenone across different diuretics.
  • Finerenone also reduced loop diuretic dose intensification, but did not prevent the initiation of new loop diuretics.

Cite This Study

Chimura et al. (2025) studied this question.

synapsesocial.com/papers/689fc962e46e096235ce1cbahttps://doi.org/10.1001/jamacardio.2025.2551
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dapagliflozin and Diuretic Use in Patients With Heart Failure and Reduced Ejection Fraction in DAPA-HF2020 · 174 citations
  2. 2Untreated heart failure: clinical and neuroendocrine effects of introducing diuretics.1987 · 513 citations
  3. 3Diuretic Therapy and Resistance in Congestive Heart Failure2001 · 325 citations