August 14, 2025

The expression of insulin signaling and N-methyl-D-aspartate receptor genes in areas of gray matter atrophy is associated with cognitive function in type 2 diabetes.

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Gray matter atrophy in type 2 diabetes is linked to cognitive function impairment, highlighting an important aspect of dementia risk.
In a sample of 271 individuals with type 2 diabetes, significant gene expression patterns were found in areas of gray matter atrophy.
Imaging transcriptomics revealed critical genes involved in insulin signaling and amyloid processing, indicating a potential pathophysiological mechanism.
Alterations in gene expression and network interactions were observed, suggesting early biomarkers for cognitive decline in type 2 diabetes.

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Implication

Retrospective analysis reveals gray matter atrophy associated with cognitive function in type 2 diabetes, suggesting underlying gene expression changes in insulin signaling and dementia pathways.

Cite This Study

Kesler et al. (2025) studied this question.

synapsesocial.com/papers/689fc962e46e096235ce1c0f https://doi.org/10.1177/13872877251364906

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Implication

Retrospective analysis reveals gray matter atrophy associated with cognitive function in type 2 diabetes, suggesting underlying gene expression changes in insulin signaling and dementia pathways.

The expression of insulin signaling and N-methyl-D-aspartate receptor genes in areas of gray matter atrophy is associated with cognitive function in type 2 diabetes.

Key Points

Discussion

Implication

Cite This Study

The expression of insulin signaling and N-methyl-D-aspartate receptor genes in areas of gray matter atrophy is associated with cognitive function in type 2 diabetes.

Key Points

Discussion

Implication

Cite This Study