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August 14, 2025

TBX5 and CHD4 Coordinately Activate Atrial Cardiomyocyte Genes to Maintain Cardiac Rhythm Homeostasis.

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Authors

MSMason SweatWSWei ShiYSYan Y. Sweat

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Overview

Research shows mutations in TBX5 and CHD4 affect gene expression in atrial cardiomyocytes, suggesting pathways to atrial fibrillation.

Key Points

  • TBX5 and CHD4 are vital for maintaining normal cardiac rhythm, with their interaction influencing crucial gene expressions.
  • Inactivation of CHD4 in atrial cardiomyocytes leads to increased vulnerability to atrial fibrillation, highlighting its protective role.
  • Multiple genomics approaches revealed TBX5's recruitment of CHD4 to 33,170 genomic regions essential for atrial gene activation.
  • CHD4's dual role as an activator and repressor suggests a complex mechanism in stabilizing atrial rhythm homeostasis.

Cite This Study

Sweat et al. (2025) studied this question.

synapsesocial.com/papers/689fc957e46e096235ce1b35https://doi.org/10.1161/circulationaha.125.073833
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