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August 12, 2025

D-glucuronyl C5-Epimerase Binds to EGFR to Suppress Kidney Fibrosis.

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Authors

XJXiaoqi JingJWJun WuJNJingru Ning

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Overview

Experimental findings demonstrate that glucuronyl c5-epimerase affects kidney fibrosis in mice, highlighting a link with EGFR signaling.

Key Points

  • Glucuronyl c5-epimerase expression is significantly reduced in kidneys affected by fibrosis.
  • Deletion of glucuronyl c5-epimerase in renal tubular cells worsens kidney fibrosis in mice.
  • Glucuronyl c5-epimerase overexpression mitigates kidney fibrosis through the TGF-β/Smad signaling pathway.
  • The study reveals that glucuronyl c5-epimerase affects EGFR signaling, which is crucial for kidney fibrosis management.

Cite This Study

Jing et al. (2025) studied this question.

synapsesocial.com/papers/689e03d9d61984b91e13cc18https://doi.org/10.1002/advs.202416216
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