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August 7, 2025Frontiers in ImmunologyOpen Access

Autoimmune disease: genetic susceptibility, environmental triggers, and immune dysregulation. Where can we develop therapies?

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Authors

MKManoj KumarLYLinda YipFWFangyuan Wang

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Overview

This review highlights genetic susceptibility and immune dysregulation in autoimmune diseases, suggesting novel therapies that target IL-2 signaling.

Key Points

  • Autoimmune diseases affect 7-10% of the global population, driven by genetic and environmental factors.
  • Immune dysregulation, particularly T cell tolerance failure, is central to autoimmune disease pathogenesis.
  • Genome-wide association studies have identified risk loci and emphasized the role of non-coding regulatory elements.
  • A new therapy targeting IL-2 receptor signaling may restore Treg function without causing systemic immunosuppression.

Cite This Study

Kumar et al. (2025) studied this question.

synapsesocial.com/papers/689dfe88d61984b91e13b8echttps://doi.org/10.3389/fimmu.2025.1626082
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