Genetic disruption of nonsense-mediated mRNA decay in neurodevelopmental disorders

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Survey identifies significant NMD gene involvement in neurodevelopmental disorders, suggesting a common pathogenic mechanism.

Nonsense-mediated mRNA decay (NMD) is crucial for mRNA quality control and gene expression regulation.
Over 50% of NMD and NMD-related genes are implicated in neurodevelopmental disorders, indicating significant enrichment.
The disruption of NMD genes can lead to embryonic lethality in model organisms, underscoring their importance.
Ongoing research into NMD's role in brain development may reveal key insights into neurodevelopmental disorders.

Montazaribarforoushi et al. (2025) studied this question.

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