A critical role for VE-cadherin in regulating actin dynamics during endothelial maturation and non-inflammatory activation via a tension-sensitive intermediate state
Research reveals that VE-cadherin regulates actin dynamics during endothelial maturation and shear stress response, indicating its role in maintaining barrier function.
Key Points
VE-cadherin plays a critical role in endothelial maturation by strengthening junctional actin recruitment for a stable monolayer.
A novel intermediate state is identified that enhances actin and integrin recruitment during non-inflammatory activation.
The study uses human umbilical vein endothelial cells (HUVEC) to investigate mechanisms of monolayer maturation and remodeling.
Findings offer insight into mechanotransduction, showing how endothelial cells adapt to shear stress for cell protection.