August 6, 2025

Quercetin and silibinin ameliorate insulin resistance by stimulating fat browning via the β3-AR/AMPK pathway in palmitate-exposed 3T3-F442A adipocytes

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Molecular simulations reveal how quercetin and silibinin activate β3-AR/AMPK pathways, enhancing adipocyte browning.

Quercetin and silibinin improve insulin resistance by stimulating adipocyte browning through β3-AR/AMPK pathways.
The study found that QC and SLB enhance expression of key markers like PGC-1α and UCP1 in adipocytes.
Molecular docking simulations characterized the interaction and binding of QC and SLB with relevant targets.
These findings highlight the potential of QC and SLB as therapeutic agents for metabolic disorders like insulin resistance.

Ge et al. (2025) studied this question.

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