This review uncovers how oxidative stress and inflammation drive vascular complications in diabetes, suggesting natural products may offer multi-target therapies.
Key Points
Chronic hyperglycemia in diabetes leads to severe vascular complications through oxidative stress and inflammation.
The interplay of multiple factors like mitochondrial dysfunction and epigenetic changes drive these pathological processes.
Natural products are shown to have multi-target effects, potentially restoring balance in redox and inflammatory responses.
Advancing natural products into clinical practice requires thorough mechanistic research and validation of their benefits.