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August 5, 2025Clinical and Experimental Pharmacology and Physiology

Recent Advances in Targeted Protein Degradation Molecular Glues as Anticancer Drugs

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Authors

YSYulin ShenWWWen WenLCL Chen

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Overview

Review highlights targeted protein degradation methods in cancer therapy, suggesting novel approaches for precision medicine.

Key Points

  • Molecular glues represent a new class of drugs that enhance targeted protein degradation in cancer cells.
  • These agents work by coupling E3 ubiquitin ligases with oncogenic proteins, activating the ubiquitin–proteasome system.
  • The review discusses strategies for degrading both nuclear and cytoplasmic cancer proteins, addressing significant challenges.
  • Insights provided aim to advance the development of precision anti-cancer therapeutics, optimizing treatment approaches.

Cite This Study

Shen et al. (2025) studied this question.

synapsesocial.com/papers/689a0f93e6551bb0af8d11b0https://doi.org/10.1111/1440-1681.70064
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