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August 4, 2025Cardiovascular DiabetologyOpen Access

Does diabetes status modify the association between the triglyceride-glucose index and major adverse cardiovascular events in patients with coronary heart disease? A systematic review and meta-analysis of longitudinal cohort studies

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Authors

SXShicong XuZZZhi‐Hui ZhangJLJing Li

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Overview

Systematic review reveals diabetes influences the relationship between triglyceride-glucose index and major adverse cardiovascular events in coronary heart disease patients.

Key Points

  • Higher triglyceride-glucose index values increase risk of major adverse cardiovascular events in both diabetic and nondiabetic patients with coronary heart disease.
  • In diabetic patients, the hazard ratio for major adverse cardiovascular events is 1.98, indicating a substantial risk increase with higher triglyceride-glucose index.
  • The study included 36 longitudinal cohort studies with 173,851 participants examining cardiovascular risks associated with triglyceride-glucose index.
  • Results point to the potential prognostic value of the triglyceride-glucose index in coronary heart disease management, especially for patients with diabetes.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/689a0f93e6551bb0af8d1005https://doi.org/10.1186/s12933-025-02890-7
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Global Burden of Cardiovascular Diseases and Risk Factors, 1990–20192020 · 11,657 citations
  2. 2The PRISMA 2020 statement: an updated guideline for reporting systematic reviews2021 · 105,432 citations