Blood Biomarkers as Optimization Tools for Computed Tomography in Mild Traumatic Brain Injury Management in Emergency Departments: A Systematic Review

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Systematic review highlights blood biomarkers guiding CT decisions in mild TBI patients, suggesting reduced imaging needs.

Blood biomarkers such as GFAP, UCH-L1, and S100B may decrease unnecessary CT scans in patients with mild traumatic brain injury.
All studies showed high sensitivity and negative predictive value for identifying clinically relevant intracranial lesions.
A systematic search included six relevant studies on blood biomarkers in adults with mild TBI and CT imaging.
Standardizing biomarker thresholds is necessary for their effective integration into clinical guidelines.

Ballesteros et al. (2025) studied this question.

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