August 4, 2025

Rapid proteasomal degradation of mutant feline McDonough sarcoma-like tyrosine kinase-3 overcomes inhibitor resistance mechanisms of acute myeloid leukemia cells

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Experimental findings show MA191 induces apoptosis in acute myeloid leukemia cells, suggesting it may bypass FLT3 inhibitor resistance mechanisms.

MA191 effectively reduces FLT3-ITD levels in acute myeloid leukemia cells, showing IC50 values of 10.16–11.6 nM.
The compound MA191 induces rapid apoptosis and demonstrates superiority over traditional FLT3 inhibitors.
In vitro and in vivo studies imply MA191's anti-leukemic effects are not hindered by existing resistance mechanisms.
MA191 shows minimal toxicity towards healthy blood cells, indicating potential for therapeutic application in leukemia treatment.

Halilovic et al. (2025) studied this question.

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Experimental findings show MA191 induces apoptosis in acute myeloid leukemia cells, suggesting it may bypass FLT3 inhibitor resistance mechanisms.