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August 4, 2025

Figure 4 from Detection of Brain Cancer Using Genome-wide Cell-free DNA Fragmentomes

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Authors

DMDimitrios MathiosNNNoushin NiknafsAAAkshaya V. Annapragada

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Overview

Analysis shows high analytical specificity of the ARTEMIS–DELFI approach in detecting HGG mutations, suggesting effective cancer screening.

Key Points

  • The ARTEMIS–DELFI approach demonstrates 90% specificity in detecting high-grade gliomas (HGGs) using cfDNA.
  • Tumor-informed mutation panel assays show an analytical specificity of 99.9%, indicating reliable detection methods.
  • Shorter cfDNA fragments are associated with tumor-specific mutations compared to non-tumor fragments, highlighting their significance.
  • Findings advance our understanding of utilizing cfDNA fragmentation in brain cancer diagnostics, potentially improving patient outcomes.

Cite This Study

Mathios et al. (2025) studied this question.

synapsesocial.com/papers/689a0f86e6551bb0af8d0943https://doi.org/10.1158/2159-8290.29819629
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