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August 4, 2025Clinical and Experimental MedicineOpen Access

Emerging CAR immunotherapies: broadening therapeutic horizons beyond cancer

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Authors

NSNatthaporn SueangoenSPSomsak Prasongtanakij

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Overview

Review outlines CAR immunotherapy's impact on cancer and emerging uses for autoimmune diseases and solid tumors.

Key Points

  • Chimeric antigen receptor (CAR) immunotherapy has significantly advanced cancer treatment, particularly in hematologic malignancies.
  • Next-generation CARs with enhanced T cell persistence improve antitumor efficacy, but challenges remain in solid tumors.
  • Innovative CAR therapies involving natural killer cells and macrophages show promise for expanding applications beyond traditional oncology.
  • Complexities in manufacturing and gene modification necessitate safe, scalable production methods for CAR therapies.

Cite This Study

Sueangoen et al. (2025) studied this question.

synapsesocial.com/papers/689a0f86e6551bb0af8d08e6https://doi.org/10.1007/s10238-025-01820-x
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