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August 3, 2025

Molecular Insights into Long COVID: Plasma Proteomics Reveals Oxidative Stress, Coagulation Cascade Activation, and Glycolytic Imbalance

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Authors

MCMohammad Mobarak H ChowdhuryAQA QuenumCRChristine Rioux‐Perreault

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Overview

Mass spectrometry reveals oxidative stress and coagulation cascade activation in long COVID patients, indicating underlying molecular processes.

Key Points

  • Core findings suggest oxidative stress plays a key role in long COVID, linking various proteins and pathways.
  • Proteomic analysis shows downregulation of the antioxidant protein PRDX6 and upregulation of oxidative stress-related proteins in PCC.
  • The study identifies significantly higher levels of proteins associated with glycolysis and coagulation in long COVID patients compared to controls.
  • Evidence of DNA damage and alteration in antioxidant markers highlights the ongoing inflammation and oxidative processes in long COVID.

Cite This Study

Chowdhury et al. (2025) studied this question.

synapsesocial.com/papers/689a0c7be6551bb0af8d07fchttps://doi.org/10.1101/2025.07.16.665198
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