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August 3, 2025Open Access

Association of COVID-19 with risks of all-cause and cause-specific mortality post-infection: A UK Biobank cohort study

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Authors

RZRuoyu ZhangYXYong XiangJQJinghong Qiu

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Overview

Prospective cohort study shows increased all-cause and cause-specific mortality risks in COVID-19 patients, highlighting comorbidity implications.

Key Points

  • COVID-19 exposure significantly elevates all-cause mortality risk across groups, with HRs of 2.39 overall and 6.29 in hospitalized cases.
  • Cause-specific mortality linked to COVID-19 includes circulatory (HR: 1.45) and digestive (HR: 1.98) diseases, among others.
  • Cox models reveal higher risk for hospitalized cases affecting 11 organ systems and 36 diseases significantly.
  • Advanced age and comorbidities like chronic kidney disease heighten all-cause mortality risks post-COVID.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/689a0c7be6551bb0af8d05dfhttps://doi.org/10.1101/2025.08.01.25332496
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