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August 3, 2025Open Access

Comparative Effectiveness of CRT-P vs CRT-D in Octogenarians With HFrEF and LBBB: A Real-World, Propensity-Matched Cohort Study

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Authors

FIFestus IbeJLJustin Riley LamPWPhuuwadith Wattanachayakul

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Overview

This cohort study evaluates 3-year mortality and hospitalization in octogenarians with HFrEF, suggesting CRT-D may reduce hospital visits without improving survival.

Key Points

  • Three-year mortality rates were similar between CRT-D and CRT-P in octogenarians (37.2% vs 39.1%).
  • CRT-D recipients had significantly fewer hospitalizations compared to CRT-P recipients (mean 4.05 vs 5.36; p = 0.032).
  • Subgroup analysis revealed modestly lower mortality for CRT-D in patients with EF ≤25% and 26-35%, though not statistically significant.
  • Female patients receiving CRT-D exhibited lower mortality rates than their male counterparts (20.0% vs 29.5%; HR 0.637).

Cite This Study

Ibe et al. (2025) studied this question.

synapsesocial.com/papers/689a0c7be6551bb0af8d05d2https://doi.org/10.1101/2025.07.31.25332554
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