Review highlights how metabolic checkpoints influence immune cell behavior in the tumor microenvironment, implying potential for enhanced cancer immunotherapy.
Key Points
Immune cell metabolism significantly affects immune responses and cancer progression within the tumor microenvironment.
Diverse metabolic phenotypes of immune cells show remarkable plasticity, impacting their activation and function.
Targeting metabolic checkpoints can reprogram immune cell phenotypes to improve antitumor immunity in cancer therapies.
Innovative strategies for manipulating metabolic networks are essential for advancing clinical applications in immunotherapy.