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August 2, 2025Frontiers in EndocrinologyOpen Access

Efficacy and safety of tirzepatide for weight loss in patients with obesity or type 2 diabetes: a systematic review and meta-analysis

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Authors

QTQiru TianYSYi SongYDYan Deng

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Overview

Meta-analysis demonstrates significant weight loss with tirzepatide in obesity and type 2 diabetes, indicating dose-dependent effects and common gastrointestinal side effects.

Key Points

  • Tirzepatide resulted in a mean weight reduction of –10.39 kg compared to placebo, indicating strong efficacy.
  • Patients with type 2 diabetes showed weight losses of –6.17 to –9.60 kg across doses, highlighting its effectiveness.
  • Adverse events occurred more frequently with tirzepatide, particularly gastrointestinal symptoms, but serious events were similar to placebo.
  • The findings support tirzepatide's use as an effective weight management therapy, suggesting mitigation strategies for side effects could enhance adherence.

Cite This Study

Tian et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d0489https://doi.org/10.3389/fendo.2025.1593134
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Tirzepatide on the Risk of Developing Type 2 Diabetes Mellitus Among the People Living With Obesity or Overweight: A Systematic Review2025
  2. 2Comparative Efficacy and Tolerability of Tirzepatide Versus Semaglutide at Varying Doses for Weight Loss in Non-diabetic Adults With Obesity: A Network Meta-Analysis of Randomized Controlled Trials2025
  3. 3Tirzepatide for the treatment of adults living with concurrent type 1 diabetes and overweight or obesity (TZP-T1D): a double-blind, placebo-matched randomised controlled trial protocol2025
  4. 4Correction: Efficacy and safety of tirzepatide for weight loss in patients with obesity or type 2 diabetes: a systematic review and meta-analysis2025
  5. 5Exploring Adults’ Experiences with Tirzepatide for Weight Loss: A Mixed-Methods Study2025