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August 2, 2025Open Access

The earliest changes in the translatome upon human T cell activation

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Authors

АСА. В. СтепановAOAoife O'ConnelPOPaul E. O’Brien

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Overview

Examining mRNA translation and gene expression in activated T cells highlights stress responses and adaptation.

Key Points

  • The activation of T cells leads to significant early changes in the translatome and gene expression.
  • Cytokine genes are rapidly upregulated while certain transcription factors are downregulated after stimulation.
  • Distinct changes in mRNA translation occur within the first four hours of T cell activation, involving specific mRNAs.
  • Understanding these early changes is crucial for accurately studying T cell signaling and activation dynamics.

Cite This Study

Степанов et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d0403https://doi.org/10.1101/2025.07.31.667903
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