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August 2, 2025International Journal of DermatologyOpen Access

MSC‐Derived Secretome and Exosomes in Dermatology: Mechanisms, Therapeutic Opportunities, and Scientific Challenges—A Narrative Review

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Authors

MCMarcela da Costa Pereira CestariRTR TovoDBDaniela Franco Bueno

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Overview

Narrative review highlights mechanisms and therapeutic potential of MSC-derived secretome and exosomes in dermatology, suggesting clinical translation requires further evaluation.

Key Points

  • MSC-derived secretome includes various components like cytokines and growth factors that support skin healing.
  • Exosomes enhance targeted microRNA delivery, playing an essential role in managing skin conditions like psoriasis and vitiligo.
  • Preclinical evidence suggests efficacy in treating diverse dermatological issues, indicating promising therapeutic avenues.
  • Challenges such as product variability and safety assessments need addressing to advance clinical use of MSC-derived treatments.

Cite This Study

Cestari et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d03d1https://doi.org/10.1111/ijd.17982
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Role of Mesenchymal Stem Cell-Derived Exosomes in Skin Moisturization and Repair: A Review2025
  2. 2The therapeutic efficacy of mesenchymal stem cells and their extracellular vesicles in the treatment of diverse skin diseases2025 · 6 citations
  3. 3Exosome therapeutics: A paradigm shift in skin repair through multidimensional immunomodulation and biomaterial-driven delivery2025 · 20 citations
  4. 4Exosomes from Adipose Tissue Mesenchymal Stem Cells, a Preliminary Study for In Vitro and In Vivo Application2025
  5. 5From laboratory to clinic: a precise treatment strategy of mesenchymal stem cells-derived exosomes pretreated by simulating disease microenvironment2025 · 7 citations