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August 2, 2025Open Access

Nanopore-based cell-free DNA fragmentation and methylation profiles from the cerebral spinal fluid of patients with lung cancer brain metastases

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Authors

TCTianqi ChenXBXiangqi BaiGBGeorgiana Burnside

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Overview

Nanopore sequencing reveals distinct cfDNA fragmentation and methylation patterns in NSCLC patients with brain metastases, indicating potential biomarkers.

Key Points

  • Nanopore sequencing identified unique fragmentation patterns in cfDNA from cerebrospinal fluid compared to plasma-derived cfDNA.
  • Cancer patients exhibited significantly lower hydroxymethylation levels in cfDNA, suggesting distinct molecular features.
  • Comparison with healthy controls highlighted significant differences in methylation and fragmentation profiles in cancer patients.
  • Findings may assist in the development of non-invasive biomarkers for assessing prognosis in NSCLC patients with brain metastases.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d035ehttps://doi.org/10.1101/2025.07.28.667300
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