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August 2, 2025

Data from Sustained Macrophage Reprogramming Is Required for CD8+ T cell–Dependent Long-Term Tumor Eradication

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Authors

CJCarolina JardimMBMarta BicaMRMariana Reis-Sobreiro

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Overview

Intratumoral myeloid cell treatment promotes CD8 T cell activation and tumor regression in mice, suggesting repeated treatment is crucial for effective antitumor immunity.

Key Points

  • Intratumoral administration of myeloid cell treatment reprogrammed tumor-associated macrophages, leading to tumor regression.
  • Single-cell sequencing showed a transient antitumor macrophage phenotype within 12 hours post-treatment, with functional changes observed by 72 hours.
  • Repeated administration of myeloid cell treatment was necessary to maintain antitumor macrophages and enhance CD8 T cell activation.
  • This research highlights the role of reactive oxygen species and TNF-α in sustaining antitumor immune responses against tumors.

Cite This Study

Jardim et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d0162https://doi.org/10.1158/2326-6066.c.7960469
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Supplementary Figure 1 from Sustained Macrophage Reprogramming Is Required for CD8<sup>+</sup> T cell–Dependent Long-Term Tumor Eradication2025
  2. 2Supplementary Figure 3 from Sustained Macrophage Reprogramming Is Required for CD8<sup>+</sup> T cell–Dependent Long-Term Tumor Eradication2025
  3. 3Supplementary Figure 2 from Sustained Macrophage Reprogramming Is Required for CD8<sup>+</sup> T cell–Dependent Long-Term Tumor Eradication2025
  4. 4Supplementary Figure 9 from Sustained Macrophage Reprogramming Is Required for CD8<sup>+</sup> T cell–Dependent Long-Term Tumor Eradication2025
  5. 5Supplementary Figure 4 from Sustained Macrophage Reprogramming Is Required for CD8<sup>+</sup> T cell–Dependent Long-Term Tumor Eradication2025