August 1, 2025Oncology ReviewsOpen Access

Fibroblast activation protein and the tumour microenvironment: challenges and therapeutic opportunities

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Authors

HLHyunwoo Lee ZAZeyad Al‐Ogaili

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Implication

This review highlights therapeutic opportunities related to fibroblast activation protein in the tumour microenvironment, implying its role in immunotherapy outcomes.

Key Points

Fibroblast activation protein is a key player in shaping the tumour microenvironment and influencing cancer therapy.
Cancer-associated fibroblasts contribute to extracellular matrix remodelling and create an immunosuppressive environment.
Interactions between FAP-positive CAFs and the immune system can affect T cell function and macrophage polarisation.
Targeting fibroblast activation protein represents a promising therapeutic strategy for enhancing cancer treatment responses.

Cite This Study

Lee et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfd8a https://doi.org/10.3389/or.2025.1617487

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Implication

This review highlights therapeutic opportunities related to fibroblast activation protein in the tumour microenvironment, implying its role in immunotherapy outcomes.

Fibroblast activation protein and the tumour microenvironment: challenges and therapeutic opportunities

Discussion

Member takes

Implication

Key Points

Cite This Study

Fibroblast activation protein and the tumour microenvironment: challenges and therapeutic opportunities

Discussion

Member takes

Implication

Key Points

Cite This Study

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Also Consider