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July 31, 2025Open Access

SATB1 maintains naive-like identity in antiviral CD8⁺ T cells by limiting chromatin remodelling at effector gene loci.

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Authors

JLJason K.C. LeeABAdele BarugahareIGIoanna Gemlund

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Overview

Integrated analysis shows SATB1 limits chromatin remodelling at effector gene loci, impacting CD8+ T cell differentiation.

Key Points

  • SATB1 is crucial for maintaining the naive state in CD8+ T cells, acting as a gatekeeper during activation.
  • Inhibition of SATB1 down regulation affects effector differentiation in response to influenza A virus infection.
  • Single-cell genomic data reveals how SATB1 restrains effector transcriptional networks in naive CD8+ T cells.
  • Targeting SATB1 modulation may enhance CD8+ T cell longevity and adaptability in immunotherapy.

Cite This Study

Lee et al. (2025) studied this question.

synapsesocial.com/papers/689a0c65e6551bb0af8cf89bhttps://doi.org/10.1101/2025.07.27.667094
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