July 31, 2025

A Systematic Integration of Current Evidence on the Role of Error-Related Negativity as a Biomarker in Psychopathology using Pairwise and Network Meta-Analyses

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Discussion

Meta-analysis reveals error-related negativity alterations across mental disorders, suggesting risk markers for early detection.

Core finding indicates error-related negativity serves as a reliable neurocognitive biomarker for mental disorders.
Data from 139 studies with 10,084 participants showed heightened ERN in OCD and anxiety, while ADHD and psychosis exhibited blunted responses.
Pairwise and network meta-analyses were utilized to analyze neural error processing across various mental health conditions.
Findings advance understanding of cognitive control dysregulation, impacting personalized intervention strategies for patients.

Riesel et al. (2025) studied this question.

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