Beyond Lactate: The Evolving Landscape of Biomarkers for Sepsis in Critical Care – A Systematic Review and Critical Analysis

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Discussion

Systematic review evaluates diagnostic and prognostic value of sepsis biomarkers in ICU, indicating challenges and future directions.

Combining established and novel biomarkers may improve sepsis management in ICU settings.
Review analyzed 45 studies on 23 biomarkers, notably procalcitonin and C-reactive protein.
Emerging biomarkers show potential for better diagnosis but require further validation.
Integration of biomarkers into clinical decision support systems could enhance sepsis outcomes.

Shibu Sasidharan (2025) studied this question.

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