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July 31, 2025Bioscientia Medicina Journal of Biomedicine and Translational ResearchOpen Access

Platelet-Rich Plasma for Burn Wound Healing in Preclinical Models: A Systematic Review of Efficacy and Biomolecular Mechanisms

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Authors

GWGeorge Dyland De Ussy WhandyraUSUdadi SadhanaYBYuriz Bakhtiar

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Overview

Systematic review evaluates platelet-rich plasma's effects on wound healing in burn injuries, indicating potential benefits but high bias risk.

Key Points

  • PRP shows potential to enhance burn wound healing based on evidence from eleven studies involving 526 animals.
  • Macroscopically, PRP accelerates wound closure in partial-thickness burns within 4-7 days and in full-thickness from day 8.
  • Biomolecularly, PRP increases fibroblast scores and elevates VEGF and EGF levels significantly post-treatment.
  • High risk of bias and methodological differences across studies limit definitive conclusions about PRP's efficacy.

Cite This Study

Whandyra et al. (2025) studied this question.

synapsesocial.com/papers/689a0c5fe6551bb0af8cf608https://doi.org/10.37275/bsm.v9i10.1398
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelet-rich Plasma for the Management of Burn Wound: A Meta-Analysis2025 · 4 citations
  2. 2Evidence Based Efficacy of Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin (PRF) in Acute and Chronic Wound Healing: A Retrospective Case Series2025
  3. 3Beyond the Species Barrier: A Systematic Review and Risk of Bias Assessment on the Efficacy, Safety, and Translational Potential of Xenogenic Platelet-Rich Plasma for Wound Healing2025
  4. 4Antimicrobial Effects of Platelet-Rich Plasma and Platelet-Rich Fibrin: A Scoping Review2025 · 1 citations
  5. 5Platelet-Rich Plasma for Wound Healing in Diabetic Patients2025 · 4 citations