July 31, 2025Open Access

Slow synaptic plasticity from the hippocampus underlies gradual mapping and fragmentation of novel spaces by grid cells

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Slow synaptic plasticity mechanisms help grid cells adapt their spatial maps during learning tasks in novel environments.
Significant shifts in grid cell spatial fields occur, particularly in successful learners, indicating a dynamic adjustment process.
Longitudinal recordings highlight co-active grid cells maintaining congruency on a two-dimensional torus during spatial learning.
The findings improve understanding of cognitive map formation and may influence strategies for enhancing spatial learning performance.

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Implication

Longitudinal observations show shifts in grid cells' spatial fields during spatial learning, indicating synaptic plasticity in the hippocampus and medial entorhinal cortex.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/689a0c5fe6551bb0af8cf5d0 https://doi.org/10.1101/2025.07.30.667696

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Implication

Longitudinal observations show shifts in grid cells' spatial fields during spatial learning, indicating synaptic plasticity in the hippocampus and medial entorhinal cortex.

Slow synaptic plasticity from the hippocampus underlies gradual mapping and fragmentation of novel spaces by grid cells

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Implication

Cite This Study

Slow synaptic plasticity from the hippocampus underlies gradual mapping and fragmentation of novel spaces by grid cells

Key Points

Discussion

Implication

Cite This Study

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