Monitoring wastewater at healthcare facilities identifies antifungal resistance trends in Candida auris, indicating improved public health surveillance.
Key Points
Wastewater-based epidemiology significantly improves the sensitivity of detecting drug-resistant Candida auris infections.
Upstream sewer monitoring at healthcare facilities revealed >90% genomic concordance with clinical isolates.
Novel resistance mutations in Candida auris were detected in wastewater samples months before appearing in clinics.
Transcriptomic profiling uncovered new adaptation mechanisms in drug-resistant Candida auris under stress conditions.